Ziprasidone-d8

Ziprasidone-d8 is intended for use as an internal standard for the quantification of ziprasidone (Cay-15031) by GC- or LC-MS. Ziprasidone is an atypical antipsychotic. It is an agonist of the serotonin (5-HT) receptor subtype 5-HT1A (EC50 = 36.31 nM for inhibition of forskolin-induced adenylate cyclase activity in HeLa cells expressing human receptors), as well as an inverse agonist of 5-HT1D receptors (IC50 = 2.69 nM) and a partial agonist of 5-HT1B receptors (EC50 = 6.17 nM) in [35S]GTPgammaS binding assays. Ziprasidone is an antagonist at 5-HT2A and dopamine D2 receptors (Kis = 1.15 and 1.29 nM, respectively) in cell-based assays. It inhibits d-amphetamine-induced hyperactivity and apomorphine-induced stereotypy in rats (ID50s = 1.53 and 2.43 mg/kg, respectively). Formulations containing ziprasidone have been used in the treatment of schizophrenia and bipolar I disorder.Formal Name: 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl-2,2,3,3,5,5,6,6-d8]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one. CAS Number: 1126745-58-1. Synonyms: CP-88,059-d8. Molecular Formula: C21H13D8ClN4OS. Formula Weight: 421.0. Purity: >99% deuterated forms (d1-d8). Formulation: (Request formulation change), A solid. Solubility: DMSO: slightly soluble, Methanol: slightly soluble. SMILES: [2H]C(C([2H])([2H])N(CCC1=C(Cl)C=C(NC(C2)=O)C2=C1)C([2H])([2H])C3([2H])[2H])([2H])N3C4=NSC5=CC=CC=C54. InChi Code: InChI=1S/C21H21ClN4OS/c22-17-13-18-15(12-20(27)23-18)11-14(17)5-6-25-7-9-26(10-8-25)21-16-3-1-2-4-19(16)28-24-21/h1-4,11,13H,5-10,12H2,(H,23,27)/i7D2,8D2,9D2,10D2. InChi Key: MVWVFYHBGMAFLY-UFBJYANTSA-N.