Zinc Pyrithione

Zinc pyrithione is a coordination complex of zinc and pyrithione that has antimicrobial, anticancer, and fungicidal activities. It is active against the bacteria E. coli, S. aureus, K. pneumoniae, A. baumannii, P. aeruginosa, E. faecium, E. faecalis, and E. cloacae (MICs = 1-4 µg/ml) and the fungus P. ovale when used at concentrations ranging from 0.01 to 10 µg/ml. Zinc pyrithione reduces tumor growth in an SCC-4 mouse xenograft model when administered at a dose of 1 mg/kg per week for six weeks. Topical application of zinc pyrithione (0.5-5% w/w) completely prevents Aspergillus growth in soy meal-derived adhesives. Formulations containing zinc pyrithione have been used in the treatment of dandruff and in the prevention of fungal growth in industrial applications.Formal Name: (T-4)-bis[1-(hydroxy-kappaO)-2(1H)-pyridinethionato-kappaS2]-zinc. CAS Number: 13463-41-7. Molecular Formula: C10H8N2O2S2Zn. Formula Weight: 317.7. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 2.5 mg/ml, DMSO: 30 mg/ml. lambdamax: 216, 244, 275 nm. SMILES: N12[O-][Zn+2]3([S]=C1C=CC=C2)[O-]N(C=CC=C4)C4=[S]3. InChi Code: InChI=1S/2C5H4NOS.Zn/c2*7-6-4-2-1-3-5(6)8,/h2*1-4H,/q2*-1,+2. InChi Key: PICXIOQBANWBIZ-UHFFFAOYSA-N.