Zinc Protoporphyrin-9

Zinc protoporphyrin-9 (ZnPPIX) is an endogenous metabolite formed during heme biosynthesis under conditions of iron insufficiency or impaired iron utilization. It also regulates heme catabolism through competitive inhibition of heme oxygenase, the rate-limiting enzyme in the heme degradation pathway that produces bilirubin and carbon monoxide. ZnPPIX has been shown to inhibit 80% of soluble guanylyl cyclase basal activity at 2.5 µM and to inactivate the NOS isoforms nNOS, iNOS, and eNOS with IC50 values of 0.8, 4, and 5 µM, respectively. ZnPPIX has been used to assess iron status and to diagnose iron disorders and has shown therapeutic potential in hyperbilirubinemia.Formal Name: (SP-4-2)-[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-kappaN21,kappaN22,kappaN23,kappaN24]-zincate(2-), dihydrogen. CAS Number: 15442-64-5. Synonyms: ZnPPIX. Molecular Formula: C34H32N4O4Zn. Formula Weight: 626.0. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: Slightly Soluble, DMSO: Slightly Soluble. lambdamax: 416 nm. SMILES: [O-]C(CCC1=C(C=C2[N]3=C4C(C)=C2CCC([O-])=O)[N-]([Zn+2]35[N]6=C7C=C(C(C=C)=C8C)[N-]5C8=C4)C(C=C6C(C=C)=C7C)=C1C)=O.[H+].[H+]. InChi Code: InChI=1S/C34H34N4O4.Zn/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25,/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42),/q,+2/p-2/b25-13-,26-13-,27-14-,28-. InChi Key: FUTVBRXUIKZACV-RGGAHWMASA-L.