Zimlovisertib
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: Zimlovisertib (PF-06650833) is an effective, selective and orally active inhibitor... more
Product information "Zimlovisertib"
Description: Zimlovisertib (PF-06650833) is an effective, selective and orally active inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4) (IC50s: 0.2 and 2.4 nM in the cell and PBMC assay). Target: IRAK. Smiles: O(C[C@@H]1[C@H](CC)[C@H](F)C(=O)N1)C=2C3=C(C=C(C(N)=O)C(OC)=C3)C=CN2. References: Lee KL, et al. Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design. J Med Chem. 2017 Jul 13,60(13):5521-5542.
| Keywords: | PF06650833, PF-06650833 |
| Supplier: | TargetMol |
| Supplier-Nr: | TQ0167 |
Properties
| Application: | Targets interleukin-1 receptor-associated kinase 4 [EC:2.7.11.1] (IRAK4) |
| MW: | 361.37 D |
| Formula: | C18H20FN3O4 |
Database Information
| CAS : | 1817626-54-2| Matching products |
| KEGG ID : | K04733 | Matching products |
Handling & Safety
| Storage: | +4°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H361 |
| P Phrases: | P201, P202, P280, P308+313, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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