Zidebactam

Zidebactam is a penicillin-binding protein 2 (PBP2) inhibitor and beta-lactam antibiotic enhancer. It inhibits P. aeruginosa PBP2 (IC50 = 0.26 µg/ml) and is selective for PBP2 over PBP1a, -1b, -3, -4, and -5/6 (IC50s = >4 µg/ml for all). Zidebactam enhances the bactericidal activity of cefepime (Cay-23633) against multidrug-resistant strains of P. aeruginosa, as well as against E. coli, Klebsiella, Enterobacter, S. marcescens, and A. baumannii. In vivo, zidebactam enhances cefepime-induced reductions in bacterial loads in mouse models of K. pneumoniae-induced peritonitis and thigh infection. Formulations containing zidebactam in combination with cefepime have been used in the treatment of various bacterial infections.Formal Name: (1R,2S,5R)-7-oxo-6-(sulfooxy)-2-[2-[(3R)-3-piperidinylcarbonyl]hydrazide], 1,6-diazabicyclo[3.2.1]octane-2-carboxylic acid. CAS Number: 1436861-97-0. Synonyms: WCK-5107. Molecular Formula: C13H21N5O7S. Formula Weight: 391.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Water: soluble. SMILES: O=C(NNC([C@H]1CNCCC1)=O)[C@@H]2CC[C@H]3N(OS(O)(=O)=O)C([N@@]2C3)=O. InChi Code: InChI=1S/C13H21N5O7S/c19-11(8-2-1-5-14-6-8)15-16-12(20)10-4-3-9-7-17(10)13(21)18(9)25-26(22,23)24/h8-10,14H,1-7H2,(H,15,19)(H,16,20)(H,22,23,24)/t8-,9-,10+/m1/s1. InChi Key: YCZPXRQPDCXTIO-BBBLOLIVSA-N.