ZG-2033

ZG-2033 is an agonist of hypoxia-inducible factor 2alpha (HIF-2alpha). It induces HIF-2alpha transcriptional activity in a reporter assay using 786-O cells expressing HIF-2alpha (EC50 = 0.49 µM). ZG-2033 (10 or 50 µM), in combination with the inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) and HIF-PH3 AKB-6548 (vadadustat, Cay-15295), increases the number of erythrocytes in a zebrafish model of doxorubicin-induced anemia. It increases the plasma levels of erythropoietin (EPO) in mice when administered at concentrations of 100 or 200 mg/kg in combination with vadadustat.Formal Name: N-(3,5-dimethoxyphenyl)-1,2-benzisothiazol-3-amine. CAS Number: 2685739-28-8. Molecular Formula: C15H14N2O2S. Formula Weight: 286.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly soluble: 0.1-1 mg/ml, DMSO: Sparingly soluble: 1-10 mg/ml. SMILES: COC1=CC(OC)=CC(NC2=NSC3=CC=CC=C32)=C1. InChi Code: InChI=1S/C15H14N2O2S/c1-18-11-7-10(8-12(9-11)19-2)16-15-13-5-3-4-6-14(13)20-17-15/h3-9H,1-2H3,(H,16,17). InChi Key: VITJWQGYLIMHDA-UHFFFAOYSA-N.