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| Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
|---|---|---|---|---|---|---|---|
| TGM-T39927-5mg | 5 mg | - |
7 - 10 business days* |
951.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: Zeteletinib hemiadipate (BOS-172738, DS-5010) is an orally active compound that... more
Product information "Zeteletinib hemiadipate"
Description: Zeteletinib hemiadipate (BOS-172738, DS-5010) is an orally active compound that functions as a selective inhibitor of RET kinase. It exhibits nanomolar potency against RET and a 300-fold selectivity towards VEGFR2. Notably, Zeteletinib hemiadipate demonstrates exceptional effectiveness against various forms of RET, including the wild type, RET V804M/L gatekeeper mutants, and the oncogenic RET mutation M918T. Additionally, Zeteletinib hemiadipate exerts potent antitumor effects. Target: Others. Smiles: OC(=O)CCCCC(O)=O.COc1cc2cc(cnc2cc1OC)-c1ccc(CC(=O)Nc2cc(no2)C(C)(C)C(F)(F)F)cn1.COc1cc2cc(cnc2cc1OC)-c1ccc(CC(=O)Nc2cc(no2)C(C)(C)C(F)(F)F)cn1. References: Yasuyuki Kaneta, et al.Abstract B173: Preclinical characterization and antitumor efficacy of DS-5010, a highly potent and selective RET inhibitor. MOLECULAR CANCERTHER APEUTICS. January 2018, Volume 17, Issue 1.
| Keywords: | Zeteletinib hemiadipate, DS-5010hemiadipate, BOS-172738 hemiadipate |
| Supplier: | TargetMol |
| Supplier-Nr: | T39927 |
Properties
| Application: | Targets proto-oncogene tyrosine-protein kinase Ret [EC:2.7.10.1] (RET) |
| MW: | 1147.098 D |
| Formula: | C56H56F6N8O12 |
Database Information
| CAS : | 2375837-06-0| Matching products |
| KEGG ID : | K05126 | Matching products |
Handling & Safety
| Storage: | +4°C |
| Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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