Zearalenone-13C18

Zearalenone-13C18 is intended for use as an internal standard for the quantification of zearalenone (Cay-11353) by GC- or LC-MS. Zearalenone is a mycotoxin that has been found in Fusarium and has estrogenic activities. It binds to human estrogen receptor alpha (ERalpha) and ERbeta (IC50s = 9 and 5.8 nM, respectively). Zearalenone induces precocious development of mammary tissues in young female pigs and prepucial enlargement in young male pigs. Zearalenone (1.5-5 mg/kg of diet) induces hyperestrogenism in pigs. It also induces degeneration of meiotic chromatin in oocytes and reduces fertility in pigs when administered at a dose of 200 µg/kg. Zearalenone has been found as a contaminant in wheat, maize, and barley and livestock feeds.Formal Name: (3S,11E)-3,4,5,6,9,10-hexahydro-14,16-dihydroxy-3-(methyl-13C)-1H-2-benzoxacyclotetradecin-1,7(8H)-dione-13C17. CAS Number: 911392-43-3. Synonyms: FES-13C18, Mycotoxin F2-13C18, Toxin F2-13C18, Zenone-13C18. Molecular Formula: [13C]18H22O5. Formula Weight: 336.2. Purity: >98%. Formulation: (Request formulation change), A 25 µg/ml solution in acetonitrile. Solubility: Acetonitrile: soluble. SMILES: O[13C]1=[13C]([13C](O[13C@@H]([13CH3])[13CH2][13CH2][13CH2][13C]([13CH2][13CH2][13CH2]/[13CH]=[13CH]/2)=O)=O)[13C]2=[13CH][13C](O)=[13CH]1. InChi Code: InChI=1S/C18H22O5/c1-12-6-5-9-14(19)8-4-2-3-7-13-10-15(20)11-16(21)17(13)18(22)23-12/h3,7,10-12,20-21H,2,4-6,8-9H2,1H3/b7-3+/t12-/m0/s1/i1+1,2+1,3+1,4+1,5+1,6+1,7+1,8+1,9+1,10+1,11+1,12+1,13+1,14+1,15+1,16+1,17+1,18+1. InChi Key: MBMQEIFVQACCCH-NMEASMPJSA-N.