Z-Phe-Tyr(tBu)-diazomethylketone

Z-Phe-Tyr(tBu)-diazomethylketone is an inhibitor of cathepsin L (Kinact = 200,000 M-1s-1). It is selective for cathepsin L over cathepsin S and cathepsin B (Kinacts = 30 and 10.3 M-1s-1, respectively). Z-Phe-Tyr(tBu)-diazomethylketone is active against bloodstream forms of T. brucei brucei clone 427-221a in vitro (EC50 = 126 µM).Formal Name: N-[(1S)-2-[[(1S)-3-diazo-1-[[4-(1,1-dimethylethoxy)phenyl]methyl]-2-oxopropyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-carbamic acid, phenylmethyl ester. CAS Number: 114014-15-2. Synonyms: Cbz-Phe-Tyr(O-t-Bu)-CHN2, Z-Phe-Tyr(tBu)-CHN2. Molecular Formula: C31H34N4O5. Formula Weight: 542.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Ethyl Acetate: 10 mg/ml. lambdamax: 254 nm. SMILES: O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@H](C(C=[N+]=[N-])=O)CC2=CC=C(OC(C)(C)C)C=C2)=O)OCC3=CC=CC=C3. InChi Code: InChI=1S/C31H34N4O5/c1-31(2,3)40-25-16-14-23(15-17-25)18-26(28(36)20-33-32)34-29(37)27(19-22-10-6-4-7-11-22)35-30(38)39-21-24-12-8-5-9-13-24/h4-17,20,26-27H,18-19,21H2,1-3H3,(H,34,37)(H,35,38)/t26-,27-/m0/s1. InChi Key: CGONKNHDBTYOOC-SVBPBHIXSA-N.