Z-FF-FMK

Z-FF-FMK is an inhibitor of cathepsin B (Ki = 2.7 nM). It inhibits cell division, cell cycle progression, DNA replication, and chromosome decondensation in isolated T. niger fertilized embryos when used at a concentration of 100 µM. Z-FF-FMK (10 µM) prevents increases in cathepsin L activity induced by amyloid-beta (1-40) (Abeta40), as well as prevents Abeta40-induced apoptosis, DNA fragmentation, and increases in cleaved poly(ADP-ribose) polymerase (PARP) levels, in primary rat cortical neurons. In vivo, Z-FF-FMK (5 nmol/animal) inhibits quinolinic acid-induced nuclear translocation of NF-kappaB, as well as inhibits quinolinic acid-induced increases in phosphorylated IkappaBalpha and IKKalpha levels, in the unilateral striatum in rats.Formal Name: N-[(1S)-2-[[(1S)-3-fluoro-2-oxo-1-(phenylmethyl)propyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-carbamic acid, phenylmethyl ester. CAS Number: 105608-85-3. Synonyms: Z-FF-Fluoromethyl Ketone, Z-Phe-Phe-CH2F. Molecular Formula: C27H27FN2O4. Formula Weight: 462.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble: >10 mg/mL. SMILES: O=C(OCC1=CC=CC=C1)N[C@H](C(N[C@@H](CC2=CC=CC=C2)C(CF)=O)=O)CC3=CC=CC=C3. InChi Code: InChI=1S/C27H27FN2O4/c28-18-25(31)23(16-20-10-4-1-5-11-20)29-26(32)24(17-21-12-6-2-7-13-21)30-27(33)34-19-22-14-8-3-9-15-22/h1-15,23-24H,16-19H2,(H,29,32)(H,30,33)/t23-,24-/m0/s1. InChi Key: CAILNONEKASNSH-ZEQRLZLVSA-N.