YIL 781 (hydrochloride)

YIL 781 is an antagonist of the growth hormone secretagogue receptor 1a (GHS-R1a, Ki = 0.017 µM). It is selective for GHS-R1a over the motilin receptor (Ki = 6 µM) and a panel of 30 receptors and enzymes (Kis = >10 µM). YIL 781 (1 µM) prevents ghrelin-induced decreases in insulin secretion in glucose-stimulated isolated rat pancreatic islets. It increases plasma insulin levels and decreases blood glucose levels in an intraperitoneal glucose tolerance test in rats when administered at doses of 0.3 or 10 mg/kg, respectively. YIL 781 (10 and 20 mg/kg) inhibits cocaine-induced hyperlocomotion in mice.Formal Name: 6-(4-fluorophenoxy)-2-methyl-3-[[(3S)-1-(1-methylethyl)-3-piperidinyl]methyl]-4(3H)-quinazolinone, monohydrochloride. CAS Number: 1640226-17-0. Molecular Formula: C24H28FN3O2 . HCl. Formula Weight: 446.0. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 100 mM, Ethanol: 100 mM. SMILES: FC1=CC=C(OC2=CC=C(N=C(C)N(C[C@H]3CCCN(C(C)C)C3)C4=O)C4=C2)C=C1.Cl. InChi Code: InChI=1S/C24H28FN3O2.ClH/c1-16(2)27-12-4-5-18(14-27)15-28-17(3)26-23-11-10-21(13-22(23)24(28)29)30-20-8-6-19(25)7-9-20,/h6-11,13,16,18H,4-5,12,14-15H2,1-3H3,1H/t18-,/m0./s1. InChi Key: QQGRMONBDBMLSP-FERBBOLQSA-N.