YC-1

YC-1 is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase. It inhibits collagen (10 µg/ml) and thrombin (0.1 U/ml) induced platelet aggregation with IC50 values of 11.7-14.6 and 57.3-59.3 µM, respectively. In the absence of NO or carbon monoxide (CO), 200 µM YC-1 increases the activity of purified soluble guanylyl cyclase 12-fold, with an ED50 value of 20 µM. At a concentration of 200 µM, YC-1 potentiates the maximal activity of soluble guanylyl cyclase in the presence of NO or CO by 40% and >3,000%, respectively.Formal Name: 5-[1-(phenylmethyl)-1H-indazol-3-yl]-2-furanmethanol. CAS Number: 170632-47-0. Molecular Formula: C19H16N2O2. Formula Weight: 304.3. Purity: >99%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (5:2): 10 µg/ml, Ethanol: 20 mg/ml. lambdamax: 225, 253, 278, 287, 326 nm. SMILES: OCC1=CC=C(C2=NN(CC3=CC=CC=C3)C4=C2C=CC=C4)O1. InChi Code: InChI=1S/C19H16N2O2/c22-13-15-10-11-18(23-15)19-16-8-4-5-9-17(16)21(20-19)12-14-6-2-1-3-7-14/h1-11,22H,12-13H2. InChi Key: OQQVFCKUDYMWGV-UHFFFAOYSA-N.