XL413 (hydrochloride)

XL413 is a potent inhibitor of Cdc7 (IC50 = 3.4 nM). It is >60, >10, and >300-fold selective for Cdc7 over CK2, PIM1, and a panel of over 100 protein kinases, respectively. XL413 inhibits the growth of MDA-MB-231T and COLO 205 cells (IC50s = 118 and 140 nM, respectively). It inhibits Cdc7-specific phosphorylation of mini-chromosome maintenance protein (MCM2) and induces cell cycle accumulation in the S and G2 phases in MDA-MB-231T and COLO 205 cells that overexpress Cdc7. In vivo, XL413 inhibits MCM2 phosphorylation (ED50 = <3 mg/kg) and reduces tumor growth in a COLO 205 mouse xenograft model when administered orally at doses of 10, 30, and 100 mg/kg.Formal Name: 8-chloro-2-(2S)-2-pyrrolidinyl-benzofuro[3,2-d]pyrimidin-4(3H)-one, monohydrochloride. CAS Number: 2062200-97-7. Molecular Formula: C14H12ClN3O2 . HCl. Formula Weight: 326.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 0.2 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 232, 289 nm. SMILES: O=C1N=C([C@@H]2CCCN2)NC3=C1OC4=C3C=C(Cl)C=C4.Cl. InChi Code: InChI=1S/C14H12ClN3O2.ClH/c15-7-3-4-10-8(6-7)11-12(20-10)14(19)18-13(17-11)9-2-1-5-16-9,/h3-4,6,9,16H,1-2,5H2,(H,17,18,19),1H/t9-,/m0./s1. InChi Key: UNDKJUKLBNARIZ-FVGYRXGTSA-N.