XIE62-1004

XIE62-1004 is an inducer of autophagy. It increases the number of p62 aggregates, as well as the number of autophagosomes and autolysosomes, in wild-type HeLa cervical cancer cells, but not in HeLa cells deficient in the gene encoding p62, SQSTM1, when used at a concentration of 10 µM. XIE62-1004 induces autophagic flux and the conversion of LC3 autophagy marker I (LC3-I) to LC3-II in HeLa cells. It increases the degradation of mutant huntingtin (mHTTQ103) protein expressed in HeLa cells.Formal Name: 2-[[[3,4-bis(phenylmethoxy)phenyl]methyl]amino]-ethanol, monohydrochloride. CAS Number: 2421146-32-7. Molecular Formula: C23H25NO3 . HCl. Formula Weight: 399.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly soluble, DMSO: Soluble, Water: Slightly soluble. SMILES: OCCNCC1=CC(OCC2=CC=CC=C2)=C(C=C1)OCC3=CC=CC=C3.Cl. InChi Code: InChI=1S/C23H25NO3.ClH/c25-14-13-24-16-21-11-12-22(26-17-19-7-3-1-4-8-19)23(15-21)27-18-20-9-5-2-6-10-20,/h1-12,15,24-25H,13-14,16-18H2,1H. InChi Key: ROURICFSUKPJOO-UHFFFAOYSA-N.