Xanthohumol
| Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
|---|---|---|---|---|---|---|---|
| CDX-X0005-M025 | 25 mg | - | - |
3 - 9 business days* |
337.00€
|
||
| CDX-X0005-M050 | 50 mg | - | - |
3 - 9 business days* |
535.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Yellow powder. Soluble in DMSO (10mg/ml) or ethanol (10mg/ml). Chemical. CAS: 6754-58-1. Formula:... more
Product information "Xanthohumol"
Yellow powder. Soluble in DMSO (10mg/ml) or ethanol (10mg/ml). Chemical. CAS: 6754-58-1. Formula: C21H22O5. MW: 354.40. Xanthohumol is a cell-permeable natural prenylated chalcone isolated from the hop plant, H. lupulus. Xanthohumol and its metabolites induce protective detoxification enzymes, at least in part via the nuclear factor erythroid-2-related factor 2 pathway. Xanthohumol can have anti-inflammatory, antioxidant, anticarcinogenic, antidiabetic and osteogenic effects. Xanthohumol binds to the N-terminal domain of p97 ATPase (VCP, valosin-containing protein), an essential protein for autophagosome maturation. Xanthohumol inhibits the function of p97 ATPase thereby impairing autophagosome maturation and resulting in accumulation of the microtubule-associated protein 1 light chain 3-II (LC3-II)1. Xanthohumol inhibits diacylglycerol acetyltransferase (DGAT) and human P450 enzymes. It also inhibits the expression of HIF-1alpha and VEGF under hypoxic conditions.
| Keywords: | 2',4,4'-Trihydroxy-6'-methoxy-3'-prenylchalcone |
| Supplier: | Chemodex |
| Supplier-Nr: | X0005 |
Properties
| Host: | Plant |
| MW: | 354,40 D |
| Formula: | C21H22O5 |
| Purity: | > 98% (NMR) |
| Format: | Solid |
Database Information
| CAS : | 6754-58-1| Matching products |
Handling & Safety
| Storage: | +4°C |
| Shipping: | +20°C (International: +20°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H317, H400 |
| P Phrases: | P273, P280 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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