WZ811

The CXC chemokine receptor-4 (CXCR4) is a G protein-coupled receptor that is specific for stromal cell-derived factor-1 (SDF-1/ CXCL12). Activation of CXCR4 promotes homing of hematopoietic stem cells, chemotaxis and quiescence of lymphocytes, and growth and metastasis of certain cancer cell types. Moreover, CXCR4 on CD4+ T-cells is used by CXCR4-selective HIV forms as a gateway for T-cell infection. WZ811 is a potent inhibitor of binding of an SDF-1 peptide mimic to CXCR4 (EC50 = 0.3 nM). It prevents SDF-1/CXCL12-mediated modulation of cAMP (EC50 = 1.2 nM) in cells and blocks SDF-1-induced Matrigel(TM) invasion by MDA-MB-231 human breast adenocarcinoma cells (EC50 = 5.2 nM). The effectiveness of WZ811 in animals remains to be elucidated.Formal Name: N1,N4-di-2-pyridinyl-1,4-benzenedimethanamine. CAS Number: 55778-02-4. Molecular Formula: C18H18N4. Formula Weight: 290.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 3 mg/ml, DMSO: 10 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 245, 305 nm. SMILES: C1(NCC2=CC=C(CNC3=CC=CC=N3)C=C2)=NC=CC=C1. InChi Code: InChI=1S/C18H18N4/c1-3-11-19-17(5-1)21-13-15-7-9-16(10-8-15)14-22-18-6-2-4-12-20-18/h1-12H,13-14H2,(H,19,21)(H,20,22). InChi Key: KBVFRXIGQQRMEF-UHFFFAOYSA-N.