WNK463

WNK463 is an inhibitor of WNK lysine-deficient protein kinase 1 (WNK1), WNK2, WNK3, and WNK4 (IC50s = 5, 1, 6, and 9 nM, respectively). It is selective for WNK1-4 over a panel of 442 kinases at 10 µM. In vivo, WNK463 (1, 3, and 10 mg/kg) decreases blood pressure, as well as increases urine output and urinary sodium and potassium excretion rates in spontaneously hypertensive rats (SHRs). It also decreases tumor growth, induces intratumoral apoptosis, and increases intratumoral levels of CD4+ and CD8+ T cells in an MC-38 mouse syngeneic colon cancer model when administered at doses of 5 and 10 mg/kg.Formal Name: N-(1,1-dimethylethyl)-1-[1-[5-[5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl]-2-pyridinyl]-4-piperidinyl]-1H-imidazole-5-carboxamide. CAS Number: 2012607-27-9. Molecular Formula: C21H24F3N7O2. Formula Weight: 463.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Methanol: Soluble. SMILES: FC(F)(F)C(O1)=NN=C1C2=CC=C(N=C2)N3CCC(N4C(C(NC(C)(C)C)=O)=CN=C4)CC3. InChi Code: InChI=1S/C21H24F3N7O2/c1-20(2,3)27-17(32)15-11-25-12-31(15)14-6-8-30(9-7-14)16-5-4-13(10-26-16)18-28-29-19(33-18)21(22,23)24/h4-5,10-12,14H,6-9H2,1-3H3,(H,27,32). InChi Key: HWSHOMMVLGBIDN-UHFFFAOYSA-N.