WM-3835

WM-3835 is an inhibitor of lysine acetyltransferase 6A (KAT6A) and KAT7 (IC50s = 17 and 30 nM, respectively). It is selective for KAT6A and KAT7 over KAT5 (IC50 = 312 nM). WM-3835 (1 µM) reduces the viability of primary mouse leukemia stem cells (LSCs), MOLM-13 and OCI-AML-3 acute myeloid lymphoma (AML) cells, as well as decreases colony formation in patient-derived primary AML cells. It induces cell cycle arrest at the sub-G1 phase and apoptosis, as well as decreases the levels of mRNA encoding homeobox protein A7 (HOXA7), in MOLM-13 cells. In vivo, WM-3835 (5 mg/kg per day) reduces tumor volume, weight, and growth rate, as well as decreases the acetylation at lysine 14 on histone 3 (H3K14), H3K12, and H3K5 in tumor cell lysates, in a PPC-1 prostate cancer mouse xenograft model.Formal Name: 4-fluoro-5-methyl-[1,1'-biphenyl]-3-carboxylic acid, 2-[(3-hydroxyphenyl)sulfonyl]hydrazide. CAS Number: 2229025-70-9. Molecular Formula: C20H17FN2O4S. Formula Weight: 400.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble: >10 mg/ml, Ethanol: Sparingly Soluble: 1-10 mg/ml. SMILES: O=C(C1=CC(C2=CC=CC=C2)=CC(C)=C1F)NNS(=O)(C3=CC(O)=CC=C3)=O. InChi Code: InChI=1S/C20H17FN2O4S/c1-13-10-15(14-6-3-2-4-7-14)11-18(19(13)21)20(25)22-23-28(26,27)17-9-5-8-16(24)12-17/h2-12,23-24H,1H3,(H,22,25). InChi Key: KVJFJJXCBRSCDY-UHFFFAOYSA-N.