WITHAFERIN A

Description: WITHAFERIN A is a novel class of NFkappaB inhibitors, which hold promise as novel anti-inflammatory agents for treatment of various inflammatory disorders and/or cancer. Target: Ferroptosis, NF-kappaB. Smiles: C[C@@H]([C@H]1CC[C@H]2[C@@H]3C[C@H]4O[C@]44[C@@H](O)C=CC(=O)[C@]4(C)[C@H]3CC[C@]12C)[C@H]1CC(C)=C(CO)C(=O)O1. References: Kaileh M , Vanden Berghe W , Heyerick A , et al. Withaferin A Strongly Elicits IkappaB Kinase beta Hyperphosphorylation Concomitant with Potent Inhibition of Its Kinase Activity[M]// An introduction to analog and digital communications /. Wiley, 2007.