WHI-P258

WHI-P258 is a quinazoline compound that modeling studies suggested would bind to the active site of JAK3 with an estimated Ki value of 72 µM. However, it is inactive at JAK3 (IC50 = >300 µM) and has been used as a negative control for structurally similar compounds that inhibit platelet aggregation and herpes simplex virus 1 (HSV-1) replication.Formal Name: 6,7-dimethoxy-N-phenyl-4-quinazolinamine. CAS Number: 21561-09-1. Molecular Formula: C16H15N3O2. Formula Weight: 281.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 15 mg/ml. lambdamax: 201, 223, 254, 346 nm. SMILES: COC1=C(OC)C=C(C(NC2=CC=CC=C2)=NC=N3)C3=C1. InChi Code: InChI=1S/C16H15N3O2/c1-20-14-8-12-13(9-15(14)21-2)17-10-18-16(12)19-11-6-4-3-5-7-11/h3-10H,1-2H3,(H,17,18,19). InChi Key: MJKCGAHOCZLYDG-UHFFFAOYSA-N.