WHI-P180

WHI-P180 is a multi-kinase inhibitor with IC50 values of 4.5 and 66 nM for the human proto-oncogene RET and kinase insert domain receptor (KDR), respectively. It also inhibits EGFR (IC50 = 4 µM) and binds to tau-tubulin kinase 1 (TTBK1, Kds = 0.46 and 0.24 µM for phosphorylated and non-phosphorylated TTBK1, respectively). WHI-P180 inhibits JAK3 and JAK3-driven graft versus host disease responses in mice receiving allogenic bone marrow and splenocyte grafts. WHI-P180 (25 mg/kg, i.p) inhibits IgE-induced vascular hyperpermeability in a mouse model of passive anaphylaxis.Formal Name: 3-[(6,7-dimethoxy-4-quinazolinyl)amino]-phenol. CAS Number: 211555-08-7. Synonyms: Janex 3. Molecular Formula: C16H15N3O3. Formula Weight: 297.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 15 mg/ml. lambdamax: 203, 228, 252, 335 nm. SMILES: COC1=C(OC)C=C(C(NC2=CC=CC(O)=C2)=NC=N3)C3=C1. InChi Code: InChI=1S/C16H15N3O3/c1-21-14-7-12-13(8-15(14)22-2)17-9-18-16(12)19-10-4-3-5-11(20)6-10/h3-9,20H,1-2H3,(H,17,18,19). InChi Key: BNDYIYYKEIXHNK-UHFFFAOYSA-N.