WAY-200070

WAY-200070 is a potent and selective agonist of estrogen receptor beta (ERbeta, IC50s = 2 and 187 nM for human full-length ERbeta and ERalpha, respectively). WAY-200070 (30 mg/kg, s.c. in mice) induces nuclear translocation of ERbeta and increases c-fos activation and dopamine levels in the striatum four hours after administration. At the same dose, it decreases depressive-like behavior in the tail suspension test. It has anxiolytic effects in mice using the four-plate and stress-induced hyperthermia tests and in zebrafish larvae using a light-dark choice behavior test. In addition, WAY-200070 improves glucose and insulin sensitivity in mouse models of diabetes.Formal Name: 7-bromo-2-(4-hydroxyphenyl)-5-benzoxazolol. CAS Number: 440122-66-7. Synonyms: WAY-00005. Molecular Formula: C13H8BrNO3. Formula Weight: 306.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 33 mg/ml, DMSO: 20 mg/ml, Ethanol: 33 mg/ml, Ethanol:PBS (pH7.2)(1:20): 0.04 mg/ml. lambdamax: 289, 324 nm. SMILES: OC1=CC(Br)=C2C(N=C(C3=CC=C(O)C=C3)O2)=C1. InChi Code: InChI=1S/C13H8BrNO3/c14-10-5-9(17)6-11-12(10)18-13(15-11)7-1-3-8(16)4-2-7/h1-6,16-17H. InChi Key: BAAILVWEAXFTSF-UHFFFAOYSA-N.