VX-765

VX-765 is a prodrug form of the caspase-1 inhibitor VRT-043198. VX-765 (50, 100, and 200 mg/kg) inhibits LPS-induced increases in serum IL-1beta levels in mice. It also reduces oxazolone-induced ear edema and levels of IL-1beta, IL-18, and IFN-gamma in ear tissue in an oxazolone-sensitized mouse model of delayed-type hypersensitivity. VX-765 reduces forepaw inflammation in a mouse model of collagen-induced arthritis in a dose-dependent manner. VX-765 (>50 mg/kg) decreases seizure duration and the number of seizures in a mouse model of acute seizures induced by hippocampal kainic acid injection, as well as delays the onset of seizures when administered at doses of 100 and 200 mg/kg. It also reduces the aggregated duration of epileptic activity in a mouse model of chronic epilepsy.Formal Name: N-(4-amino-3-chlorobenzoyl)-3-methyl-L-valyl-N-[(2R,3S)-2-ethoxytetrahydro-5-oxo-3-furanyl]-L-prolinamide. CAS Number: 273404-37-8. Synonyms: Belnacasan. Molecular Formula: C24H33ClN4O6. Formula Weight: 509.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS (pH 7.2) (1:9): 0.1 mg/ml. lambdamax: 281 nm. SMILES: NC1=C(Cl)C=C(C(N[C@@H](C(C)(C)C)C(N2CCC[C@H]2C(N[C@@H]3[C@H](OCC)OC(C3)=O)=O)=O)=O)C=C1. InChi Code: InChI=1S/C24H33ClN4O6/c1-5-34-23-16(12-18(30)35-23)27-21(32)17-7-6-10-29(17)22(33)19(24(2,3)4)28-20(31)13-8-9-15(26)14(25)11-13/h8-9,11,16-17,19,23H,5-7,10,12,26H2,1-4H3,(H,27,32)(H,28,31)/t16-,17-,19+,23+/m0/s1. InChi Key: SJDDOCKBXFJEJB-MOKWFATOSA-N.