VU0364770

VU0364770 is a positive allosteric modulator of metabotropic glutamate receptor 4 (mGluR4, EC50 = 1.1 µM in a calcium mobilization assay). It is also a positive allosteric modulator of mGluR6 (EC50 = 6.8 µM) and an antagonist of mGluR5 (IC50 = 17.9 µM). VU0364770 binds to monoamine oxidase A (MAO-A) and MAO-B (Kis = 8.5 and 7.2 µM, respectively), as well as the human norepinephrine transporter in a panel of 68 receptors, ion channels, and transporters at 10 µM. It decreases haloperidol-induced catalepsy and reduces increases in the number of premature reactions in response to a light cue, indicating improved attentional control, in a 6-hydroxydopamine (6-OHDA, Cay-25330) rat model of Parkinson's disease when administered at a dose of 56.6 mg/kg.Formal Name: N-(3-chlorophenyl)-2-pyridinecarboxamide. CAS Number: 61350-00-3. Molecular Formula: C12H9ClN2O. Formula Weight: 232.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml, DMSO: 25 mg/ml, Ethanol: 5 mg/ml. lambdamax: 219, 277 nm. SMILES: ClC1=CC(NC(C2=NC=CC=C2)=O)=CC=C1. InChi Code: InChI=1S/C12H9ClN2O/c13-9-4-3-5-10(8-9)15-12(16)11-6-1-2-7-14-11/h1-8H,(H,15,16). InChi Key: SUYUTNCKIOLMAJ-UHFFFAOYSA-N.