VPC 23019

Sphingosine-1-phosphate (S1P, Cay-62570) is a bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis. It exerts its activity by binding to five distinct G protein-coupled receptors, S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8. VPC 23019 is an aryl amide-containing S1P analog that acts as a competitive antagonist at both S1P1 and S1P3 receptors (pKis = 7.86 and 5.93, respectively). It can inhibit S1P-induced migration of thyroid cancer cells, ovarian cancer cells, and neural stem cells.Formal Name: (R)-2-amino-3-((3-octylphenyl)amino)-3-oxopropyl dihydrogen phosphate. CAS Number: 449173-19-7. Molecular Formula: C17H29N2O5P. Formula Weight: 372.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 0.25 mg/ml. lambdamax: 245 nm. SMILES: O=C([C@H](N)COP(O)(O)=O)NC1=CC(CCCCCCCC)=CC=C1. InChi Code: InChI=1S/C17H29N2O5P/c1-2-3-4-5-6-7-9-14-10-8-11-15(12-14)19-17(20)16(18)13-24-25(21,22)23/h8,10-12,16H,2-7,9,13,18H2,1H3,(H,19,20)(H2,21,22,23)/t16-/m1/s1. InChi Key: MRUSUGVVWGNKFE-MRXNPFEDSA-N.