Volasertib
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: Volasertib (BI 6727) (BI-6727) is a potent inhibitor of PLK1 (IC50: 0.87 nM),... more
Product information "Volasertib"
Description: Volasertib (BI 6727) (BI-6727) is a potent inhibitor of PLK1 (IC50: 0.87 nM), inducing mitotic arrest and apoptosis. It also inhibits PLK2/PLK3 (IC50s: 5/56 nM). Target: Apoptosis, PLK. Smiles: CC[C@H]1N(C(C)C)c2nc(Nc3ccc(cc3OC)C(=O)N[C@H]3CC[C@@H](CC3)N3CCN(CC4CC4)CC3)ncc2N(C)C1=O. References: Rudolph D, et al. BI 6727, a Polo-like kinase inhibitor with improved pharmacokinetic profile and broad antitumor activity. Clin Cancer Res. 2009 May 1,15(9):3094-102.
| Keywords: | BI 6727 |
| Supplier: | TargetMol |
| Supplier-Nr: | T6019 |
Properties
| Application: | Targets polo-like kinase 1 [EC:2.7.11.21] (PLK1) |
| MW: | 618.81 D |
| Formula: | C34H50N8O3 |
Database Information
| CAS : | 755038-65-4| Matching products |
| KEGG ID : | K06631 | Matching products |
| Protein Atlas Nr. : | Ser/Thr Phosphorylation |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Danger |
| GHS Hazard Pictograms: |
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| H Phrases: | H300, H315, H319, H361, H373 |
| P Phrases: | P201, P202, P260, P264, P270, P280, P314, P321, P330, P301+P310, P302+P352, P305+P351+P338, P308+P313, P332+P313, P337+P313, P362+P364, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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