Vitamin K4

Vitamin K4 is a synthetic form of vitamin K and the diacetate form of the provitamin vitamin K3 (Cay-15950). It inhibits proliferation of PC3 prostate cancer cells (IC50 = 20.94 µM). Vitamin K4 (20 and 40 µM) induces cell cycle arrest at the S phase and mitochondrial apoptosis in PC3 cells. It inhibits canonical and non-canonical activation of the NOD-like receptor protein 3 (NLRP3) inflammasome in mouse bone marrow-derived macrophages (BMDMs) when used at a concentration of 5 µM. Vitamin K4 (4 mg/kg) decreases the production of IL-1beta and peritoneal neutrophil infiltration in a mouse model of monosodium urate-induced NLRP3-dependent peritonitis.Formal Name: 2-methyl-1,4-diacetate1,4-naphthalenediol. CAS Number: 573-20-6. Synonyms: Acetomenaphthone, Menadiol diacetate, NSC 403062, Vitamin K diacetate. Molecular Formula: C15H14O4. Formula Weight: 258.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 1 mg/ml. lambdamax: 226 nm. SMILES: O=C(C)OC1=CC(C)=C(C2=C1C=CC=C2)OC(C)=O. InChi Code: InChI=1S/C15H14O4/c1-9-8-14(18-10(2)16)12-6-4-5-7-13(12)15(9)19-11(3)17/h4-8H,1-3H3. InChi Key: RYWSYCQQUDFMAU-UHFFFAOYSA-N.