Vilanterol (triphenylacetate)

Vilanterol is a long-acting agonist of the beta2-adrenergic receptor (beta2-AR). It selectively induces cAMP accumulation in CHO cells expressing the beta2-AR over the beta1- and beta3-ARs (EC50s = 0.4, 398, and 794 nM for the human receptors, respectively). Vilanterol inhibits contractions induced by electrical stimulation in isolated superfused guinea pig trachea strips. It inhibits bronchospasms induced by histamine (Cay-33828) in guinea pigs when administered via nebulization (EC50 = 30 µM). Formulations containing vilanterol, in combination with fluticasone, have been used in the treatment of chronic obstructive pulmonary disease (COPD) and asthma.Formal Name: alpha1R-[[[6-[2-[(2,6-dichlorophenyl)methoxy]ethoxy]hexyl]amino]methyl]-4-hydroxy-1,3-benzenedimethanol, alpha,alpha-diphenyl-benzeneacetic acid, monotriphenylacetate. CAS Number: 503070-58-4. Synonyms: GW 642444M. Molecular Formula: C24H33Cl2NO5 . C20H16O2. Formula Weight: 774.8. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Methanol: Soluble. SMILES: ClC1=C(COCCOCCCCCCNC[C@H](O)C2=CC(CO)=C(O)C=C2)C(Cl)=CC=C1.O=C(O)C(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5. InChi Code: InChI=1S/C24H33Cl2NO5.C20H16O2/c25-21-6-5-7-22(26)20(21)17-32-13-12-31-11-4-2-1-3-10-27-15-24(30)18-8-9-23(29)19(14-18)16-28,21-19(22)20(16-10-4-1-5-11-16,17-12-6-2-7-13-17)18-14-8-3-9-15-18/h5-9,14,24,27-30H,1-4,10-13,15-17H2,1-15H,(H,21,22)/t24-,/m0./s1. InChi Key: KLOLZALDXGTNQE-JIDHJSLPSA-N.