Vilanterol

Vilanterol is a long-acting agonist of the beta2-adrenergic receptor (beta2-AR). It selectively induces cAMP accumulation in CHO cells expressing the beta2-AR over the beta1- and beta3-ARs (EC50s = 0.4, 398, and 794 nM for the human receptors, respectively). Vilanterol inhibits contractions induced by electrical stimulation in isolated superfused guinea pig trachea strips. It inhibits bronchospasms induced by histamine (Cay-33828) in guinea pigs when administered via nebulization (EC50 = 30 µM). Formulations containing vilanterol, in combination with fluticasone, have been used in the treatment of chronic obstructive pulmonary disease (COPD) and asthma.Formal Name: alpha1R-[[[6-[2-[(2,6-dichlorophenyl)methoxy]ethoxy]hexyl]amino]methyl]-4-hydroxy-1,3-benzenedimethanol. CAS Number: 503068-34-6. Synonyms: GSK642444, GW 642444. Molecular Formula: C24H33Cl2NO5. Formula Weight: 486.4. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 30 mg/ml, DMSO: 10 mg/ml, Ethanol: 30 mg/ml. SMILES: ClC1=C(COCCOCCCCCCNC[C@H](O)C2=CC=C(O)C(CO)=C2)C(Cl)=CC=C1. InChi Code: InChI=1S/C24H33Cl2NO5/c25-21-6-5-7-22(26)20(21)17-32-13-12-31-11-4-2-1-3-10-27-15-24(30)18-8-9-23(29)19(14-18)16-28/h5-9,14,24,27-30H,1-4,10-13,15-17H2/t24-/m0/s1. InChi Key: DAFYYTQWSAWIGS-DEOSSOPVSA-N.