Vigabatrin-13C-d2 (hydrochloride)

Vigabatrin-13C-d2 is intended for use as an internal standard for the quantification of vigabatrin (Cay-9000976) by GC- or LC-MS. Vigabatrin is an irreversible GABA transaminase (GABA-T) inhibitor. It inhibits rat brain GABA-T when used at a concentration of 0.1 mM. Vigabatrin is selective for rat brain GABA-T over P. fluorescens GABA-T at 10 mM and is 100-fold selective over glutamic acid decarboxylase (GAD). Vigabatrin (1,500 mg/kg) decreases brain GABA-T activity without affecting GAD activity in mice. It reduces the incidence of myoclonus in a mouse model of audiogenic seizures. Vigabatrin also increases the electroconvulsive threshold in mouse model of maximal electroshock-induced seizures and reduces the number of clonic convulsions induced by pentylenetetrazol (PTZ, Cay-18682) in mice. Formulations containing vigabatrin have been used in the treatment of seizures and infantile spasms.Formal Name: 4-aminohex-5-enoic-6-13C-6,6-d2 acid, monohydrochloride. CAS Number: 2749628-08-6. Synonyms: gamma-Vinyl GABA-13C-d2. Molecular Formula: C5[13C]H9D2NO2 . HCl. Formula Weight: 168.6. Purity: >99% deuterated forms (d1-d2). Formulation: (Request formulation change), A solid. Solubility: Water: soluble. SMILES: NC(CCC(O)=O)/C=[13C]([2H])/[2H].Cl. InChi Code: InChI=1S/C6H11NO2.ClH/c1-2-5(7)3-4-6(8)9,/h2,5H,1,3-4,7H2,(H,8,9),1H/i1+1D2,. InChi Key: FBNKOYLPAMUOHS-YSJJXQNZSA-N.