VH 032 amide C7 Acid

VH 032 amide C7 acid is a precursor in the synthesis of proteolysis-targeting chimeras (PROTACs) that contains a terminal carboxylic acid conjugated via a heptyl linker to VHL ligand 1 (Cay-21591), which binds to von Hippel-Lindau (VHL) E3 ligase. It has been used in the synthesis of PROTACs targeting anaplastic lymphoma kinase (ALK) in cancer cells.Formal Name: N-(8-carboxy-1-oxooctyl)-3-methyl-L-valyl-4R-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide. CAS Number: 2172819-76-8. Molecular Formula: C31H44N4O6S. Formula Weight: 600.8. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble: >10 mg/ml, Ethanol: Sparingly soluble: 1-10 mg/ml, PBS (pH 7.2): Slightly soluble: 0.1-1 mg/ml. SMILES: O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@@H]3C[C@@H](O)CN3C([C@H](C(C)(C)C)NC(CCCCCCCC(O)=O)=O)=O. InChi Code: InChI=1S/C31H44N4O6S/c1-20-27(42-19-33-20)22-14-12-21(13-15-22)17-32-29(40)24-16-23(36)18-35(24)30(41)28(31(2,3)4)34-25(37)10-8-6-5-7-9-11-26(38)39/h12-15,19,23-24,28,36H,5-11,16-18H2,1-4H3,(H,32,40)(H,34,37)(H,38,39)/t23-,24+,28-/m1/s1. InChi Key: WBFMUQOHZVFNHP-FMGHJNRGSA-N.