Verteporfin

Verteporfin is a photosensitizer used during photodynamic therapy to eliminate abnormal blood vessels in the eye that are associated with conditions such as macular degeneration. It accumulates in these abnormal blood vessels and, when activated by nonthermal red light with a wavelength of 693 nm in the presence of oxygen, produces a highly reactive short-lived singlet oxygen and other reactive oxygen radicals, generating local damage to the endothelium and vessel occlusion. Verteporfin can also inhibit autophagosome formation by directly targeting and modifying p62, a scaffold and adaptor protein that binds both polyubiquitinated proteins destined for degradation and LC3 on autophagosomal membranes.Formal Name: (4R,4aS)-rel-18-ethenyl-4,4a-dihydro-3,4-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-24H,26H-benzo[b]porphine-9,13-dipropanoic acid, monomethyl ester. CAS Number: 129497-78-5. Synonyms: BPD-MA, CL 318,952. Molecular Formula: C41H42N4O8. Formula Weight: 718.8. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 3 mg/ml, DMF:PBS (pH 7.2), (1:7): 0.1 mg/ml, DMSO: 50 mg/ml. lambdamax: 214, 345, 435, 566, 682 nm. SMILES: CC1=C(CCC(O)=O)/C([N]=C1/C=C(C(C=C)=C/2C)\[NH]C2=C/3)=C/C4=C(CCC(OC)=O)C(C)=C(/C=C5[N]=C3C6=CC=C(C(OC)=O)[C@@H](C(OC)=O)[C@@]\56C)[NH]4. InChi Code: InChI=1S/C41H42N4O8/c1-9-23-20(2)29-17-34-27-13-10-26(39(49)52-7)38(40(50)53-8)41(27,5)35(45-34)19-30-22(4)25(12-15-37(48)51-6)33(44-30)18-32-24(11-14-36(46)47)21(3)28(43-32)16-31(23)42-29/h9-10,13,16-19,38,42,44H,1,11-12,14-15H2,2-8H3,(H,46,47)/b28-. InChi Key: YTZALCGQUPRCGW-MXVXOLGGSA-N.