Verapamil (hydrochloride)

Verapamil (hydrochloride)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay14288-1 1 g -

6 - 10 business days*

39.00€
 
Verapamil is the prototypical blocker of L-type calcium channels that produces... more
Product information "Verapamil (hydrochloride)"
Verapamil is the prototypical blocker of L-type calcium channels that produces excitation-contraction uncoupling in cardiac muscle by preventing the slow-inward current of calcium ions. Verapamil can also block calcium fluxes in vascular smooth muscle. It has both peripheral and coronary vasodilator effects (IC50 = 0.38 µM in guinea pig aortic strip) and has been used to control hypertension, angina, cardiac arrhythmia, and vascular headaches. Verapamil has also been used in cell biology as an inhibitor of drug efflux pump proteins such as P-glycoprotein, which are often over-expressed in certain tumor cell lines.Formal Name: alpha-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-alpha-(1-methylethyl)-benzeneacetonitrile, monohydrochloride. CAS Number: 152-11-4. Synonyms: NSC 272366, NSC 657799, (±)-Verapamil. Molecular Formula: C27H38N2O4 . HCl. Formula Weight: 491.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 16.7 mg/ml, DMSO: 10 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): 0.25 mg/ml. lambdamax: 205, 231, 280 nm. SMILES: COC1=CC=C(C(C(C)C)(C#N)CCCN(C)CCC2=CC=C(OC)C(OC)=C2)C=C1OC.Cl. InChi Code: InChI=1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6,/h9-12,17-18,20H,8,13-16H2,1-7H3,1H. InChi Key: DOQPXTMNIUCOSY-UHFFFAOYSA-N.
Keywords: NSC 272366, NSC 657799, alpha-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-alpha-(1-methylethyl)-benzeneacetonitrile, monohydrochloride
Supplier: Cayman Chemical
Supplier-Nr: 14288

Properties

Application: L-type Calcium channel blocker
MW: 491.1 D
Formula: C27H38N2O4 . HCl
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 152-11-4| Matching products
KEGG ID : K04850 | Matching products

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H300, H311, H330
P Phrases: P260, P264, P270, P271, P280, P284, P301+310, P302+352, P304+340, P310, P312, P320, P321, P330, P361+364, P403+233, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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