Vatalanib Dihydrochloride (N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine Dihydrochlorid

Vatalanib Dihydrochloride (N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine Dihydrochlorid
Item number Size Datasheet Manual SDS Delivery time Quantity Price
V2120-70A.25 25 mg - -

3 - 19 business days*

216.00€
 
Vatalanib is a potent, selective, orally active inhibitor of the VEGFR tyrosine kinases VEGFR-1... more
Product information "Vatalanib Dihydrochloride (N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine Dihydrochlorid"
Vatalanib is a potent, selective, orally active inhibitor of the VEGFR tyrosine kinases VEGFR-1 (Flt-1, IC50=77nM) and VEGFR-2 (FLK-1/KDR, IC50=37nM), with slightly higher potency against the latter. At higher concentrations, other tyrosine kinases are also inhibited, including PDGFR-b (IC50=580nM), c-KIT (IC50=730nM), FLT-4 (IC50=660nM) and c-FMS (IC50=1.4uM). On the other hand, vatalanib is not active against the EGFR, c-SRC, v-ABL, and protein kinase Ca (IC50 > 10uM). Solubility: Soluble in DMSO at 10-20mg/ml with warming, very poorly soluble in ethanol, soluble in water at 100 mg/ml, buffers, serum, or other additives may increase or decrease the aqueous solubility. Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Supplier: United States Biological
Supplier-Nr: V2120-70A

Properties

MW: 419.73
Formula: C20H15ClN4¥2HCl
Format: Highly Purified

Database Information

CAS : 212141-51-0| Matching products

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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