Varenicline (tartrate)

Varenicline is a full agonist of alpha7 subunit-containing neuronal nicotinic acetylcholine receptors (nAChRs, EC50 = 18 µM) and a partial agonist of alpha4beta2 subunit-containing nAChRs (EC50 = 2.3 µM). Formulations containing varenicline have been used as aids in smoking cessation.Formal Name: 7,8,9,10-tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine-(2R,3R)-dihydroxybutanedioate. CAS Number: 375815-87-5. Synonyms: CP 526,555-18. Molecular Formula: C13H13N3 . C4H6O6. Formula Weight: 361.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: Insolube, DMSO: 5 mg/ml, Ethanol: Insolube, PBS (pH 7.2): 10 mg/ml. lambdamax: 204, 236, 320 nm. SMILES: O[C@H]([C@@H](O)C(O)=O)C(O)=O.C12=CC3=C(N=CC=N3)C=C1C4CNCC2C4. InChi Code: InChI=1S/C13H13N3.C4H6O6/c1-2-16-13-5-11-9-3-8(6-14-7-9)10(11)4-12(13)15-1,5-1(3(7)8)2(6)4(9)10/h1-2,4-5,8-9,14H,3,6-7H2,1-2,5-6H,(H,7,8)(H,9,10). InChi Key: TWYFGYXQSYOKLK-UHFFFAOYSA-N.