Valproic acid sodium salt

Description: Valproic acid sodium salt (Sodium Valproate) is the sodium salt form of valproic acid with anti-epileptic activity. Valproic acid sodium salt is converted into its active form, valproate ion, in blood. Although the mechanism of action remains to be elucidated, Valproic acid sodium salt increases concentrations of gamma-aminobutyric acid (GABA) in the brain, probably due to inhibition of the enzymes responsible for the catabolism of GABA. This potentiates the synaptic actions of GABA. Valproic acid sodium salt may also affect potassium channels, thereby creating a direct membrane-stabilizing effect. Target: GABA Receptor, Autophagy, Mitophagy, HIV Protease, HDAC, Gamma-secretase. Smiles: [Na+].CCCC(CCC)C([O-])=O. References: Phiel CJ, et al. J Biol Chem, 2001, 276(39), 36734-36741.