Valemetostat

Valemetostat is a dual inhibitor of enhancer of zeste homolog 1 (EZH1) and EZH2. It inhibits polycomb repressive complex 2 (PRC2) containing EZH1 or EZH2 as the catalytic subunit in cell-free assays (IC50s = 8.4 and 2.5 nM, respectively). Valemetostat inhibits trimethylation of histone H3 lysine 27 in HCT116 cells (IC50 = 0.44 nM). It inhibits the growth of Karpas-422 diffuse large B cell lymphoma (DLBCL) cells (GI50 = 4.8 nM).Formal Name: (2R)-7-chloro-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-2-[trans-4-(dimethylamino)cyclohexyl]-2,4-dimethyl-1,3-benzodioxole-5-carboxamide. CAS Number: 1809336-39-7. Synonyms: DS-3201b, (R)-OR-S2. Molecular Formula: C26H34ClN3O4. Formula Weight: 488.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble. lambdamax: 216 nm. SMILES: CC1=C2C(O[C@@](O2)([C@]3([H])CC[C@H](CC3)N(C)C)C)=C(C=C1C(NCC4=C(C=C(NC4=O)C)C)=O)Cl. InChi Code: InChI=1S/C26H34ClN3O4/c1-14-11-15(2)29-25(32)20(14)13-28-24(31)19-12-21(27)23-22(16(19)3)33-26(4,34-23)17-7-9-18(10-8-17)30(5)6/h11-12,17-18H,7-10,13H2,1-6H3,(H,28,31)(H,29,32)/t17-,18-,26-/m1/s1. InChi Key: SSDRNUPMYCFXGM-UYPAYLBCSA-N.