Valbenazine

Valbenazine is an inhibitor of vesicular monoamine transporter 2 (VMAT2, Kis = 110 and 150 nM in rat striatum homogenates and human platelets, respectively). It is selective for VMAT2 over a panel of 80 receptors, transporters, and ion channels, including the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT2A, and 5-HT2B and dopamine D1 and D2 receptors. Valbenazine induces ptosis in rats, indicating norepinephrine depletion. Formulations containing valbenazine have been used in the treatment of tardive dyskinesia.Formal Name: L-valine, (2R,3R,11bR)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-yl ester. CAS Number: 1025504-45-3. Synonyms: NBI-98854. Molecular Formula: C24H38N2O4. Formula Weight: 418.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS(pH7.2) (1:2): 0.33 mg/ml, DMSO: 25 mg/ml, Ethanol: 10 mg/ml. SMILES: COC1=C(OC)C=C(CCN2[C@]3([H])C[C@@H](OC([C@@H](N)C(C)C)=O)[C@H](CC(C)C)C2)C3=C1. InChi Code: InChI=1S/C24H38N2O4/c1-14(2)9-17-13-26-8-7-16-10-21(28-5)22(29-6)11-18(16)19(26)12-20(17)30-24(27)23(25)15(3)4/h10-11,14-15,17,19-20,23H,7-9,12-13,25H2,1-6H3/t17-,19-,20-,23+/m1/s1. InChi Key: GEJDGVNQKABXKG-CFKGEZKQSA-N.