V-0219 (hydrochloride)

V-0219 is a positive allosteric modulator (PAM) of the glucagon-like peptide 1 receptor (GLP-1R). It is selective for GLP-1R over a panel of 54 other receptors, ion channels, and transporters at 10 µM. V-0219 (0.001-1 nM) potentiates GLP-1-induced cAMP accumulation in HEK293 cells expressing human GLP-1R. It also potentiates GLP-1-induced insulin secretion in INS-1E rat insulinoma cells, an effect that can be blocked by the GLP-1R antagonist exendin (9-39) amide. V-0219 improves glucose tolerance in wild-type, but not Glp1r knockout, mice when administered at a dose of 0.1 mg/kg and enhances a reduction in food intake induced by the GLP-1R agonist exendin-4 in rats at 0.001 mg/kg.Formal Name: 4-[[1-[[3-[4-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]methyl]-3-piperidinyl]methyl]-morpholine, monohydrochloride. CAS Number: 2922283-73-4. Molecular Formula: C20H25F3N4O2 . HCl. Formula Weight: 446.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Water: Soluble. SMILES: FC(F)(F)C(C=C1)=CC=C1C2=NOC(CN(CCC3)CC3CN4CCOCC4)=N2.Cl. InChi Code: InChI=1S/C20H25F3N4O2.ClH/c21-20(22,23)17-5-3-16(4-6-17)19-24-18(29-25-19)14-27-7-1-2-15(13-27)12-26-8-10-28-11-9-26,/h3-6,15H,1-2,7-14H2,1H. InChi Key: PTRIYHLSBQMDQM-UHFFFAOYSA-N.