UVI3003

UVI3003 is a full antagonist of RXR that demonstrates potent, nanomolar binding affinity. At 1 µM, UVI3003 does not affect the corepressor interaction capacity of the RARalpha subunit in the RAR-RXR heterodimer configuration. This compound can be used to isolate the contribution of RXR to the function of RXR heterodimers.Formal Name: 3-[4-hydroxy-3-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-(pentyloxy)-2-naphthalenyl]phenyl]-2-propenoic acid. CAS Number: 847239-17-2. Molecular Formula: C28H36O4. Formula Weight: 436.6. Purity: >90%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 15 mg/ml, Ethanol: 20 mg/ml. SMILES: OC1=C(C2=C(OCCCCC)C=C(C(C)(C)CCC3(C)C)C3=C2)C=C(/C=C/C(O)=O)C=C1. InChi Code: InChI=1S/C28H36O4/c1-6-7-8-15-32-25-18-23-22(27(2,3)13-14-28(23,4)5)17-21(25)20-16-19(9-11-24(20)29)10-12-26(30)31/h9-12,16-18,29H,6-8,13-15H2,1-5H3,(H,30,31)/b12-10+. InChi Key: APJSHECCIRQQDV-ZRDIBKRKSA-N.