USP8-IN-3

USP8-IN-3 is an inhibitor of ubiquitin-specific protease 8 (USP8, IC50 = 4 µM). It inhibits the growth of H1975 non-small cell lung cancer (NSCLC) and GH3 rat pituitary cells (GI50s = 6.01 and 37.03 µM).Formal Name: N-(4-nitrophenyl)-N'-[1-[6-(trifluoromethyl)-2-pyridinyl]-4-piperidinyl]-thiourea. CAS Number: 2477651-10-6. Synonyms: Ubiquitin-specific Protease 8-IN-3, Ubiquitin-specific Protease 8 Inhibitor 3, USP 8 Inhibitor 3. Molecular Formula: C18H18F3N5O2S. Formula Weight: 425.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly soluble: 0.1-1 mg/ml, DMSO: Sparingly soluble: 1-10 mg/ml. SMILES: S=C(NC1CCN(CC1)C2=CC=CC(C(F)(F)F)=N2)NC(C=C3)=CC=C3[N+]([O-])=O. InChi Code: InChI=1S/C18H18F3N5O2S/c19-18(20,21)15-2-1-3-16(24-15)25-10-8-13(9-11-25)23-17(29)22-12-4-6-14(7-5-12)26(27)28/h1-7,13H,8-11H2,(H2,22,23,29). InChi Key: DYHHEFBWFATDAN-UHFFFAOYSA-N.