USP8-IN-1

USP8-IN-1 is an inhibitor of ubiquitin-specific protease 8 (USP8, IC50 = 2.6 µM). It is selective for USP8 over USP7 (IC50 = >20 µM). USP8-IN-1 inhibits colony formation by H1975 non-small cell lung cancer (NSCLC) cells (IC50 = 30.8 µM).Formal Name: 4-(2-amino-4-methoxyphenyl)-N-(4-nitrophenyl)-1-piperazinecarbothioamide. CAS Number: 2477650-96-5. Synonyms: DC-U43-10, Ubiquitin-specific Protease 8 Inhibitor 1, USP8 Inhibitor 1. Molecular Formula: C18H21N5O3S. Formula Weight: 387.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly soluble: 0.1-1 mg/ml, DMSO: Sparingly soluble: 1-10 mg/ml. SMILES: S=C(N1CCN(CC1)C2=CC=C(C=C2N)OC)NC(C=C3)=CC=C3[N+]([O-])=O. InChi Code: InChI=1S/C18H21N5O3S/c1-26-15-6-7-17(16(19)12-15)21-8-10-22(11-9-21)18(27)20-13-2-4-14(5-3-13)23(24)25/h2-7,12H,8-11,19H2,1H3,(H,20,27). InChi Key: LYQOAIJZQPUZEF-UHFFFAOYSA-N.