UTP (sodium salt)

UTP is a nucleotide and dual agonist of purinergic P2Y2 and P2Y4 receptors (EC50s = 55 and 80 nM, respectively, for stimulation of phospholipase C in 1321N1 cells expressing human receptors). It is selective for P2Y2 and P2Y4 receptors over P2Y6 receptors (EC50 = >10,000 nM). UTP stimulates proliferation of PANC-1 cells (EC50 = 13.1 µM), an effect that can be prevented by siRNA against the P2Y2 receptor. It induces vasoconstriction in perfused isolated canine epicardial coronary artery in a concentration-dependent manner. UTP is formed from uridine monophosphate (UMP) by two sequential phosphorylations and can be converted to cytidine 5'-triphosphate (CTP, Cay-18147). It also reacts with glucose-1-phosphate (Cay-30566) to form UDP-glucose (Cay-15602), a precursor in the biosynthesis of glycogen.Formal Name: uridine 5'-(tetrahydrogen triphosphate), trisodium salt. CAS Number: 19817-92-6. Synonyms: NSC 20260, UTP. Molecular Formula: C9H12N2O15P3 . 3Na. Formula Weight: 550.1. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 10 mg/ml. lambdamax: 262 nm. SMILES: O=P(OP(OP(O)([O-])=O)([O-])=O)([O-])OC[C@@H]1[C@@H](O)[C@@H](O)[C@@](N2C(NC(C=C2)=O)=O)([H])O1.[Na+].[Na+].[Na+]. InChi Code: InChI=1S/C9H15N2O15P3.3Na/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18,,,/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18),,,/q,3*+1/p-3/t4-,6-,7-,8-,,,/m1.../s1. InChi Key: MMJGIWFJVDOPJF-LLWADOMFSA-K.