UGT8 Inhibitor 19

UGT8 inhibitor 19 is an inhibitor of UDP-galactose ceramide galactosyltransferase (UGT8), also known as ceramide galactosyltranferase (CGT, IC50 = 0.2 nM). It is selective for UGT8 over UGT1A1, -1A6, -2B7, -2B15, and -2B17 (IC50s = >10 µM for all). In vivo, UGT8 inhibitor 19 inhibits the synthesis of galactosylceramide (GalCer) and sulfatide (SFT) in juvenile mouse brain (ED50s = <3 mg/kg for both) and adult mouse kidney when administered at doses of 3, 10, and 30 mg/kg.Formal Name: N-[(1S)-1-methyl-2-(trifluoromethoxy)ethyl]-carbamic acid, 1-[3-[(methylamino)carbonyl]-7-(trifluoromethyl)thieno[3,2-b]pyridin-5-yl]-4-piperidinyl ester. CAS Number: 2414349-93-0. Synonyms: Ceramide Galactosyltransferase Inhibitor 19, CGT Inhibitor 19, UDP-galactose Ceramide Galactosyltransferase Inhibitor 19. Molecular Formula: C20H22F6N4O4S. Formula Weight: 528.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 25 mg/ml. lambdamax: 218, 252 nm. SMILES: CNC(C(C1=NC(N2CCC(CC2)OC(N[C@@H](C)COC(F)(F)F)=O)=C3)=CSC1=C3C(F)(F)F)=O. InChi Code: InChI=1S/C20H22F6N4O4S/c1-10(8-33-20(24,25)26)28-18(32)34-11-3-5-30(6-4-11)14-7-13(19(21,22)23)16-15(29-14)12(9-35-16)17(31)27-2/h7,9-11H,3-6,8H2,1-2H3,(H,27,31)(H,28,32)/t10-/m0/s1. InChi Key: UQQUABVWYAPTIQ-JTQLQIEISA-N.