UCSF924

UCSF924 is a dopamine D4 receptor agonist. It selectively induces beta-arrestin translocation over Galphai/o signaling in HEK293T cells expressing human dopamine D4 receptors by 7.4-fold at 1 µM. UCSF924 selectively induces cAMP accumulation in HEK293T cells expressing human dopamine D4 receptors (EC50 = 4.2 nM) over HEK293T cells expressing human dopamine D2 or dopamine D3 receptors (EC50s = >10 µM for both) and induces beta-arrestin recruitment in HTLA cells expressing human dopamine D4 receptors over a panel of HTLA cells expressing one of 320 non-olfactory G protein-coupled receptors (GPCRs) at 1 µM.Formal Name: 6-methyl-2-[[(3-phenoxypropyl)amino]methyl]-4-quinolinol. CAS Number: 1434515-70-4. Molecular Formula: C20H22N2O2. Formula Weight: 322.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly Soluble: 0.1-1 mg/ml, DMSO: Sparingly Soluble: 1-10 mg/ml. SMILES: OC1=CC(CNCCCOC2=CC=CC=C2)=NC3=C1C=C(C)C=C3. InChi Code: InChI=1S/C20H22N2O2/c1-15-8-9-19-18(12-15)20(23)13-16(22-19)14-21-10-5-11-24-17-6-3-2-4-7-17/h2-4,6-9,12-13,21H,5,10-11,14H2,1H3,(H,22,23). InChi Key: RPHDOVLXDYWDGF-UHFFFAOYSA-N.