UCM-05194 (ammonium salt)

UCM-05194 is an agonist of lysophosphatidic acid receptor 1 (LPA1). It induces calcium mobilization in RH7777 cells expressing LPA1 (EC50 = 0.24 µM). It is selective for LPA1 over LPA2 and LPA3 at 10 µM and is 10-fold selective over LPA5 and 50-fold selective over LPA4, LPA6, and autotaxin. UCM-05194 (1 µM) induces neurite retraction in, and migration of, B103 rat neuroblastoma cells overexpressing LPA1. It induces receptor internalization and neuronal desensitization in the same cells when used at a concentration of 1 µM and reduces the firing activity of primary rat neonatal dorsal root ganglia (DRG) neurons with repeated application at 10 µM. UCM-05194 (10 mg/kg) reduces acetic acid-induced writhing and hind paw mechanical hypersensitivity in mice.Formal Name: benzenedecanoic acid, (1S)-1-(bromomethyl)-2-(phosphonooxy)ethyl ester, monoammonium salt. Molecular Formula: C19H29BrO6P . NH4. Formula Weight: 482.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Ethanol: Slightly soluble, Water: Soluble. SMILES: O=C(CCCCCCCCCC1=CC=CC=C1)O[C@@H](COP(O)([O-])=O)CBr.[NH4+]. InChi Code: InChI=1S/C19H30BrO6P.H3N/c20-15-18(16-25-27(22,23)24)26-19(21)14-10-5-3-1-2-4-7-11-17-12-8-6-9-13-17,/h6,8-9,12-13,18H,1-5,7,10-11,14-16H2,(H2,22,23,24),1H3/t18-,/m1./s1. InChi Key: UKZAXCXBQFDZCW-GMUIIQOCSA-N.