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Description: GABAA receptor antagonist that binds the picrotoxin site and stabilizes the inactive form of the channel via allosteric interaction. Accelerates the decay of GABA-induced Cl- currents with little effect on peak amplitude. Also inhibits 5-HT3A receptors via a similar mechanism. Target: GABA Receptor. Smiles: CC(C)(C)OC(=O)c1ncn-2c1C(C)(C)Nc1ccccc-21. References: Dillon,GH et al. Mol Pharmacol. 1993 Oct,44(4):860-5.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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