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Description: U0126, an effective and selective non-competitive inhibitor of MAP kinase, inhibits MEK-1 and MEK-2 with IC50 values of 0.07 and 0.06 µM respectively. U0126 inhibits autophagy and mitophagy. Target: Autophagy, MEK, Mitophagy. Smiles: N#CC(=C(SC=1C=CC=CC1N)N)C(C#N)=C(SC=2C=CC=CC2N)N. References: Bessard A, et al. RNAi-mediated ERK2 knockdown inhibits growth of tumor cells in vitro and in vivo. Oncogene. 2008 Sep 11,27(40):5315-25.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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