U-73122

White to off-white solid. Soluble in methylene chloride or chloroform (10mg/ml). Slightly soluble in DMSO (2mg/ml), DMF (2mg/ml) or 100% ethanol (1mg/ml). Sparingly soluble in aqueous solutions. See also Solubility Note below. Chemical. CAS: 112648-68-7. Formula: C29H40N2O3. MW: 464.6. Gasdermin D N-terminal fragment (GSDMD-N)-induced pyroptosis inhibitor. Protects against GSDMD-N cytotoxicity in macrophages or against lethal infection in mice. Useful agent for inflammasome research. Potent cell permeable phospholipase C (PLC) , phospholipase A2 and 5-LO (5-lipoxygenase) inhibitor. Affects the phospholipases by inhibiting the hydrolysis of PPI (phosphatidylinositol) to IP3 (inositol triphosphate), which in turn leads to a drop in cytosolic Ca2+. Potent inhibitor of the SERCA pump in smooth muscle. Potently inhibits Ca2+-release from isolated smooth muscle cells independent of its effect on PLC. Inhibits agonist-induced platelet aggregation. Potently inhibits human polymorphonuclear neutrophil adhesion on biological surfaces and exhibits antinociceptive activity in vivo. Shown to inhibit agonist-induced down-regulation of muscarinic receptors in SK-N-SH neuroblastoma cells. Activates TRPM4 and inhibits TRPM3 channels. Potent human telomerase inhibitor.