TVB-3166

Description: TVB-3166 induces apoptosis and inhibits in-vivo xenograft tumor growth. TVB-3166 is a reversible and selective fatty acid synthase inhibitor (IC50s: 42 nM and 81 nM for biochemical FASN and cellular palmitate synthesis, respectively). Target: Apoptosis, Fatty Acid Synthase, Others. Smiles: CC=1C(=CC(C(=O)N2CC(C2)C3=CC=C(C#N)C=C3)=C(C)C1)C=4C(C)=C(C)NN4. References: Ventura R, et al. Inhibition of de novo Palmitate Synthesis by Fatty Acid Synthase Induces Apoptosis in Tumor Cells by Remodeling Cell Membranes, Inhibiting Signaling Pathways, and Reprogramming Gene Expression. EBioMedicine. 2015 Jul 2,2(8):808-24.